Researchers are working to develop a universal coronavirus vaccine in order to prevent a potential future pandemic that may be even more deadly than the current COVID-19 situation. The goal is to create a vaccine that can be effective against various coronaviruses, not just the one that causes COVID-19. Current vaccines from Moderna and Pfizer/BioNTech target a specific spike protein of SARS-CoV2, but scientists are looking to develop a vaccine that targets multiple proteins shared by various coronaviruses. This approach would generate a more durable and broad immune response against potential future viruses. Some researchers are working on a DNA vaccine administered through a nasal spray that targets the spike protein, membrane, and envelope proteins of coronaviruses. It is hoped that this vaccine will be helpful against any form of coronavirus that may emerge. Existing vaccines have proven to be somewhat effective against new strains of SARS-CoV-2, and companies are developing booster shots to enhance protection against these variants. It is necessary to stay prepared for the possible emergence of new coronavirus strains, as researchers believe there is a high probability of another pandemic. These innovative efforts aim to protect against future coronavirus threats and minimize their impact.