Researchers at the Statewide California Earthquake Center are using physics-based computational models on high-performance computing systems to study seismic hazards in Southern California. The CyberShake Study 22.12 is the largest set of earthquake simulations ever conducted by the SCEC and relies on updated 3D seismic velocity models and new computational methods to refine ground motion simulations. By using detailed information about Earth’s structure from fault models and seismic velocity models, CyberShake is able to produce information about where strong shaking is most likely to occur. The study also involves collaboration across multiple scientific disciplines and is providing useful information about seismic hazards to the general public. Previous results from CyberShake have proven beneficial to organizations, such as the U.S. Geological Survey and the Building Seismic Safety Council, and it has been integrated into updated building code recommendations for Southern California. Although it’s too early to determine the impact of CyberShake 22.12, the team anticipates ongoing developments and hopes to use high-performance computing to produce accurate seismic hazard information that advances public safety. The findings from CyberShake 22.12 were presented at the 2023 SCEC Annual Meeting in Palm Springs, California.